ea0029oc1.3 | Pituitary Clinical I | ICEECE2012
Bianchi A.
, Grottoli S.
, Bogazzi F.
, Colao A.
, Sicolo N.
, Cannavo S.
, Ghigo E.
, De Marinis L.
, Acrostudy Group Italian
ACROSTUDY is an international observational study to evaluate efficacy and safety of long-term treatment with pegvisomant (PEGA) in acromegaly. ACROSTUDY Italy was started in 2007 and we report data from the first 185 patients (93M, 92F, mean age, range, 49.9 y; 1783.8 y) treated with PEGA (mean duration, range, 3.2 y, 0.18.5 y), from 24 centers, until 01/2010. Before and during PEGA, IGF1, GH-Ab, liver enzymes, metabolic parameters and pituitary MRI were assessed....